Nippi manufactures gelatin for medical applications, particularly for use in vivo. Gelatin is made by heating collagen to unravel its triple helix structure and denature it. This denaturation is irreversible, meaning that once collagen has turned into gelatin, it cannot revert back to collagen. While collagen is almost insoluble in water, gelatin is easily soluble. Nippi’s low endotoxin gelatin is produced under a clean manufacturing environment and strict quality control. It can be used in a wide range of applications, including stabilizers for injectable drugs, substrates for drug delivery, and raw materials for medical devices and regenerative medicine.
Low endotoxin gelatin products
Nippi's low endotoxin gelatin significantly reduces endotoxins, which are fever-inducing substances derived from microorganisms, compared to conventional gelatin (≤ 10 EU/g). As a result, it is suitable for use in applications where the immune system strongly reacts to endotoxins. The product is manufactured under strict quality control, ensuring high quality and safety. It boasts high reliability for medical use and is also available as a research reagent and pharmaceutical raw material (Japanese Pharmacopoeia "Purified Gelatin").
MediGelatin HMG-BP
With a high gel strength (≥ 250g), it is ideal for applications that require physical strength. The raw material used is porcine skin, traceable to the breeding farm. Through alkaline treatment, microorganisms are annihilated, and the product is then manufactured in a clean environment, ensuring high quality. The manufacturing process includes virus inactivation and sterile filtration, minimizing the risk of microbial contamination. In terms of safety for biological systems, it shows negative results in both intradermal reaction tests and antigenicity tests.
Nippi High-grade Gelatin AP series
This is a non-gelling grade of gelatin derived from porcine skin. It has a proven track record as a stabilizer for injectable drugs.